Professor Wherry is in the Department of Microbiology in the Perelman School of Medicine at the University of Pennsylvania.
A major goal of his laboratory is to understand the mechanisms of T-cell exhaustion and to develop approaches to reinvigorate the immune system in settings where it fails, including chronic infections and cancer. His group is using a variety of approaches, including multiparameter flow cytometry, systems biology, global gene expression profiling and genetically modified mice, to define cellular and transcriptional pathways involved in T-cell exhaustion and normal memory T-cell differentiation.
Following his PhD from Thomas Jefferson University in 2000, Professor Wherry did postdoctoral research at Emory University under Rafi Ahmed. In 2005, he was appointed Assistant Professor in the Immunology Program at The Wistar Institute and joined University of Pennsylvania’s Microbiology Department in 2010. In October 2012, Professor Wherry was appointed Director of the Penn Institute for Immunology, whose mission is to advance our knowledge of the basic immunology of inflammation, autoimmunity, cancer, transplantation and infection and to translate this new knowledge to novel strategies for diagnosis, prevention and therapeutic intervention.