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Kymab presents two e-posters at the American Association for Cancer Research Virtual Annual Meeting

White blood cells

Source: iStock/Dr_Microbe

Cambridge, UK; 22 June 2020: Kymab, a clinical-stage biopharmaceutical company developing antibody-based therapeutics, today announced that e-posters relating to Kymab's lead immune-oncology programs, KY1044 and KY1043, will be presented at the American Association for Cancer Research ("AACR") Virtual Annual Meeting II, being held June 22-24, 2020.   

The e-posters are available on the AACR website; the details are as follows:

Abstract # 2134

Title: High ICOS/FOXP3 Tregs content in the tumor microenvironment is associated with poorer survival in patients with hepatocellular carcinoma

Session Type:               Poster Session

Session Category:       Tumor Biology

E-Poster Number:        1590  

Abstract # 2780

Title: KY1043, a novel CD25-directed PD-L1 IL-2 immunocytokine, delivers potent anti-tumor activity in vivo via an expansion of a Tcf1hi PD-1+ CD8+ T cell population

Session Type:              Poster Session

Session Category:      Therapeutic Antibodies 3

E-Poster Number:       4542   

KY1044 is a human monoclonal IgG1 that selectively binds to Inducible T cell CO-stimulator (ICOS), a protein expressed at high levels on immunosuppressive regulatory T cells and at lower levels on effector T cells. KY1044 is designed to exert anti-tumor activity through preferential depletion of intra-tumoral regulatory T cells and stimulation (agonism) of ICOS-positive effector T cells. A Phase 1/2 clinical trial of KY1044 in patients with advanced solid tumors as a monotherapy and in combination with an anti PD-L1 (atezolizumab) is ongoing.  

KY1043 is a human monoclonal antibody that provides targeted immune checkpoint inhibition coupled with dose-dependent anti-tumor activity by combining Kymab’s proprietary PD-L1 blocking antibody and a reduced potency, or attenuated, version of the cytokine IL-2 in a single immunocytokine. KY1043 is designed to block immunosuppressive "checkpoint" signals, to allow the immune system to recognize and kill tumors while also localizing IL-2 delivery. These combined activities should increase immune cell recruitment and expansion and anti-tumor activity in the tumor microenvironment.

###ENDS###

Notes to Editors

Read the PDF version of the official release.

About Kymab

Kymab is a clinical-stage biopharmaceutical company developing a deep pipeline of novel antibody-based therapies in a broad range of indications. The Company generates its product candidates using its proprietary, integrated platforms collectively called IntelliSelect®. Kymab's platforms have been designed to maximize the diversity of human antibodies produced in response to immunization with antigens. Selecting from a broad diversity of fully human antibodies allows for the identification of antibodies with optimal drug-like properties.

For more information on Kymab please see http://www.kymab.com.

Forward-looking statements

This announcement includes forward-looking statements that involve risks, uncertainties and other factors, many of which are outside of our control, that could cause actual results to differ materially from the results discussed in the forward-looking statements. Forward-looking statements include statements concerning our plans, objectives, goals, future events, performance and/or other information that is not historical information. All such forward-looking statements are expressly qualified by these cautionary statements and any other cautionary statements which may accompany the forward-looking statements. We undertake no obligation to publicly update or revise forward-looking statements to reflect subsequent events or circumstances after the date made, except as required by law.

For further information contact

Kymab

Anne Hyland anne.hyland@kymab.com 

Brandon Lewis brandon.lewis@kymab.com 

+44 (0) 1223 833 301


Media UK

Consilium Strategic Communications

Mary-Jane Elliott / Sukaina Virji / Melissa Gardiner

kymab@consilium-comms.com 

Tel: +44 (0) 20 3709 5700

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